Emory University    Department of Cell Biology    Imaging Core    Whitehead Biomedical Research Building
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Selected Publications
2011-2012
Xing L, and Bassell GJ.  mRNA localization: an orchestration of assembly, traffic and synthesis.Traffic. 2012; Aug 22 PubMed Wu CH, Fallini C, Ticozzi N, Keagle PJ, Sapp PC, Piotrowska K, Lowe P, Koppers M, McKenna-Yasek D, Baron DM, Kost JE, Gonzalez-Perez P, Fox AD, Adams J, Taroni F, Tiloca C, Leclerc AL, Chafe SC, Mangroo D, Moore MJ, Zitzewitz JA, Xu ZS, van den Berg LH, Glass JD, Siciliano G, Cirulli ET, Goldstein DB, Salachas F, Meininger V, Rossoll W, Ratti A, Gellera C, Bosco DA, Bassell GJ,  Silani V, Drory VE, Brown RH, Landers JE. Mutations in the profilin 1 gene cause familial amyotrophic lateral sclerosis.Nature. 2012; Jul 15 PubMed Emory News Dammer EB, Fallini C, Gozal YM, Duong DM, Rossoll W, Xu P, Lah JJ, Levey AI, Peng J, Bassell GJ,  and Seyfried NT. Coaggregation of RNA-Binding Proteins in a Model of TDP-43 Proteinopathy with Selective RGG Motif Methylation and a Role for RRM1 Ubiquitination.PLoS One. 2012; Jun 21 PubMed Udagawa T, Swanger SA, Takeuchi K, Kim JH, Nalavadi V, Shin J, Lorenz LJ, Zukin RS, Bassell GJ,  and Richter JD. Bidirectional control of mRNA translation and synaptic plasticity by the cytoplasmic polyadenylation complex.Mol Cell. 2012; Jul 27 PubMed Fallini C, Bassell GJ,  and Rossoll W. The ALS disease protein TDP-43 is actively transported in motor neuron axons and regulates axon outgrowth.Hum Mol Genet. 2012; Aug 15 PubMed EMORY Health Now Blog Ceci M, Welshhans K, Ciotti MT, Brandi R, Parisi C, Paoletti F, Pistillo L, Bassell GJ,  and Cattaneo A. RACK1 is a ribosome scaffold protein for β-actin mRNA/ZBP1 complex.PLoS One. 2012; Apr 16 PubMed Wilhelm JC, Xu M, Cucoranu D, Chmielewski S, Holmes T, Lau KS, Bassell GJ,  and English AW. Cooperative roles of BDNF expression in neurons and Schwann cells are modulated by exercise to facilitate nerve regeneration.J Neurosci. 2012; Apr 4 PubMed Nalavadi VC, Muddashetty RS, Gross C, and Bassell GJ.  Dephosphorylation-Induced Ubiquitination and Degradation of FMRP in Dendrites: A Role in Immediate Early mGluR-Stimulated Translation.J Neurosci. 2012; Feb 22 PubMed Xing L, Yao X, Williams KR, and Bassell GJ.  Negative regulation of RhoA translation and signaling by hnRNP-Q1 affects cellular morphogenesis.Mol Biol Cell. 2012; Feb 29 PubMed Fallini C, Bassell GJ , and Rossoll W. Spinal muscular atrophy: The role of SMN in axonal mRNA regulation.Brain Res 2012; Jan 28 PubMed Gross C and Bassell GJ.  Excess protein synthesis in FXS patient lymphoblastoid cells can be rescued with a p110β-selective inhibitor.Mol Med. 2011; Dec 7 PubMed Bassell GJ.  Fragile balance: RNA editing tunes the synapse.Nat Neurosci. 2011; Nov 23 PubMed Liu-Yesucevitz L, Bassell GJ , Gitler AD, Hart AC, Klann E, Richter JD, Warren ST, Wolozin B. Local RNA translation at the synapse and in disease.J Neurosci. 2011; Nov 9 PubMed Han L, Wen Z, Lynn RC, Baudet ML, Holt CE, Sasaki Y, Bassell GJ , Zheng JQ. Regulation of chemotropic guidance of nerve growth cones by microRNA.Mol Brain. 2011; Nov 3 PubMed Willis DE, Xu M, Donnelly CJ, Tep C, Kendall M, Erenstheyn M, English AW, Schanen NC, Kirn-Safran CB, Yoon SO, Bassell GJ , Twiss JL. Axonal Localization of transgene mRNA in mature PNS and CNS neurons.J Neurosci. 2011; Oct 12 PubMed Swanger SA, Yao X, Gross C, Bassell GJ.  Automated 4D analysis of dendritic spine morphology: applications to stimulus-induced spine remodeling and pharmacological rescue in a disease model.Mol Brain. 2011; Oct 7 PubMed Donnelly CJ, Willis DE, Xu M, Tep C, Jiang C, Yoo S, Schanen NC, Kirn-Safran CB, van Minnen J, English A, Yoon SO, Bassell GJ. , Twiss JL. Limited availability of ZBP1 restricts axonal mRNA localization and nerve regeneration capacity. EMBO J. 2011; Sep 30 PubMed Gross C, Berry-Kravis EM, Bassell GJ.  Therapeutic Strategies in Fragile X Syndrome: Dysregulated mGluR Signaling and Beyond.Neuropsychopharmacology. 2011; Jul 27 PubMed Welshhans K, Bassell GJ.  Netrin-1-induced local β-actin synthesis and growth cone guidance requires zipcode binding protein 1. J Neurosci. 2011; Jul 6 PubMed Pak C, Garshasbi M, Kahrizi K, Gross C, Apponi LH, Noto JJ, Kelly SM, Leung SW, Tzschach A, Behjati F, Abedini SS, Mohseni M, Jensen LR, Hu H, Huang B, Stahley SN, Liu G, Williams KR, Burdick S, Feng Y, Sanyal S, Bassell GJ , Ropers HH, Najmabadi H, Corbett AH, Moberg KH, Kuss AW. Mutation of the conserved polyadenosine RNA binding protein, ZC3H14/dNab2, impairs neural function in Drosophila and humans. Proc Natl Acad Sci U S A. 2011; Jul 26 PubMed Muddashetty RS, Nalavadi VC, Gross C, Yao X, Xing L, Laur O, Warren ST, Bassell GJ. Reversible Inhibition of PSD-95 mRNA Translation by miR-125a, FMRP Phosphorylation, and mGluR Signaling. Mol Cell. 2011 Jun 10;42(5):673-88 PubMed Emory press release Swanger SA, Bassell GJ. Making and breaking synapses through local mRNA regulation. Curr Opin Genet Dev. 2011; Apr 27 PubMed Gross C, Yao X, Pong DL, Jeromin A, Bassell GJ. Fragile X Mental Retardation protein regulates protein expression and mRNA translation of the potassium channel, Kv4.2. J Neurosci. 2011;31:15:5693-5698 abstract Swanger SA, Bassell GJ, Gross C. High-Resolution Fluorescence In Situ Hybridization to Detect mRNAs in Neuronal Compartments In Vitro and In Vivo. Methods Mol Biol. 2011;714:103-123 PubMed Fallini C, Zhang H, Su Y, Silani V, Singer RH, Rossoll W, Bassell GJ. The Survival of Motor Neuron (SMN) Protein Interacts with the mRNA-Binding Protein HuD and Regulates Localization of Poly(A) mRNA in Primary Motor Neuron Axons. J Neurosci. 2011 Mar 9;31:3914-25. PubMed Alzforum News This Week in The Journal Ivanova T, Matthews A, Gross C, Mappus RC, Gollnick C, Swanson A, Bassell GJ, Liu RC. Arc/Arg3.1 mRNA expression reveals a subcellular trace of prior sound exposure in adult primary auditory cortex. Neuroscience. 2011 Feb 18. PubMed Peter CJ, Evans M, Thayanithy V, Taniguchi-Ishigaki N, Bach I, Kolpak A, Bassell GJ, Rossoll W, Lorson CL, Bao ZZ, Androphy EJ. The COPI vesicle complex binds and moves with survival motor neuron within axons. Hum Mol Genet. 2011 Feb 22. PubMed
2009-2010
Kan MC, Oruganty-Das A, Cooper-Morgan A, Jin G, Swanger SA, Bassell GJ, Florman H, van Leyen K, Richter JD.. CPEB4 is a cell survival protein retained in the nucleus upon ischemia or endoplasmic reticulum calcium depletion. Mol Cell Biol. 2010 Dec;30:5658-71. PubMed Gross C, Nakamoto M, Yao X, Chan CB, Yim SY, Ye K, Warren ST, Bassell GJ. Excess phosphoinositide 3-kinase subunit synthesis and activity as a novel therapeutic target in fragile X syndrome. J Neurosci. 2010 Aug 11;30:10624-38. PubMed This Week in The Journal Emory press releasel Sasaki Y, Welshhans K, Wen Z, Yao J, Xu M, Goshima Y, Zheng JQ, Bassell GJ. Phosphorylation of Zipcode Binding Protein 1 Is Required for Brain-Derived Neurotrophic Factor Signaling of Local beta-Actin Synthesis and Growth Cone Turning. J Neurosci. 2010 Jul 14;30:9349-58. PubMed This Week in The Journal Fallini C, Bassell GJ, Rossoll W. High-efficiency transfection of cultured primary motor neurons to study protein localization, trafficking, and function. Mol Neurodegener. 2010 Apr 21;5:17 PubMed Alzforum News Li C, Bassell GJ, Sasaki Y. Fragile X Mental Retardation Protein is Involved in Protein Synthesis-Dependent Collapse of Growth Cones Induced by Semaphorin-3A. Front Neural Circuits. 2009;3:11. PubMed Santangelo PJ, Lifland AW, Curt P, Sasaki Y, Bassell GJ, Lindquist ME, Crowe JE Jr. Single molecule-sensitive probes for imaging RNA in live cells. Nat Methods. 2009 May;6(5):347-9. Epub 2009 Apr 6. PubMed Rossoll W, Bassell GJ. Spinal muscular atrophy and a model for survival of motor neuron protein function in axonal ribonucleoprotein complexes.  Results Probl Cell Differ. 2009;48:289-326. PubMed Muddashetty R, Bassell GJ. A boost in microRNAs shapes up the neuron. EMBO J. 2009 Mar 18;28(6):617-8. PubMed
2007-2008
Bassell GJ and Warren ST. Fragile x syndrome: Loss of local mRNA regulation shaping synaptic development and function. Neuron, 2008, 60(2):201-214. PubMed  / PDF Narayan U, Nalavadi V, Nakamoto M, Thomas G, Ceman S, Bassell GJ and Warren ST. S6K1 phosphorylates and regulates FMRP with the neuronal protein synthesis dependent mTOR signaling cascade. JBC, 2008, 283(27):18478-18482. PubMed  / PDF Dictenberg JB, Swanger SA, Antar LN, Singer RH, and Bassell GJ. A direct role for FMRP in activity-dependent dendritic mRNA transport links filopodial-spine morphogenesis to fragile X syndrome. Developmental Cell, 2008, 14(6);926-939. PubMed  / PDF Oprea GE, McWhorter ML, Rossoll W, Muller S, Krawczak M, Bassell GJ, Beattie CE and Wirth B. Plastin-3 is a protective modifier of SMN1 in spinal muscular atrophy. Science, 2008, 320(5875):524-227. PubMed  / PDF Bassell GJ and Gross C. Reducing glutamate signaling pays off in fragile X. Nature Medicine, 2008, 14(3):249-250. PubMed  / PDF Wang H, Dictenberg J, Ku L, Bassell GJ and Feng Y. Dynamic association of FMRP as an mRNP between microtubules and translating polyribosomes. Molecular Biology of the Cell, 2008, 19(1):105-114. PubMed  / PDF Narayanan U, Nalavadi V, Nakamoto M, Pallas D, Ceman C, Bassell GJ and Warren ST. mGluR-dependent FMRP dephosphorylation in dendrites reveals an early and dynamic phase of neuronal translation. Journal of Neuroscience, 2007, 27(52):14349-14357. PubMed  / PDF Willis DE, Sasaki Y, Mesngon M, Merianda TT, Williams GG, Kendall M, Smith DS, Bassell GJ and Twiss JL. Extracellular stimuli specifically regulate localized levels of individual neuronal mRNAs. Journal of Cell Biology, 2007, 178(6):965-980. PubMed  / PDF Nakamoto M, Nalavadi V, Epstein MP, Narayanan Y, Bassell GJ and Warren ST. Fragile X Mental Retardation protein deficiency leads to spontaneous mGluR5-dependent internalization of AMPA receptors. PNAS, 2007, 104(39):15537-15542. PubMed  / PDF Muddashetty R, Kelic S, Gross C, Xu M and Bassell GJ. Dysregulated mGluR-dependent translation of AMPA receptor and PSD-95 mRNAs in a mouse model of fragile x syndrome. Journal of Neuroscience, 2007, 27(20):5338-5348. PubMed  / PDF
2005-2006
Carrel TL, McWhorter ML, Workman E, Zhang HL, Lorson C, Bassell, G.J., Burghes AH and Beattie CE. SMN function in motor axons does not require efficient oligomerization of Sm protein binding. Journal of Neuroscience, 2006, 26(43):11014-11022. PubMed  /  PDF Kiebler M and Bassell, G.J.. Neuronal RNA granules: movers and makers. Neuron, 2006, 51(6):685-690. PubMed  /  PDF Yao J, Sasaki Y, Wen Z, Bassell, G.J. and Zheng JQ. An essential role for β-actin mRNA localization and translation in Ca-dependent growth cone guidance. Nature Neuroscience, 2006, 9(10):1265-1273. PubMed  /  PDF Zhang HL, Xing L, Rossoll WM Wichterle H, Singer RH and Bassell, G.J.. Survival of Motor Neuron protein (SMN) forms a multiprotein complex with Gemins and traffics to neuronal processes and growth cones. Journal of Neuroscience, 2006, 26(33): 8622-8632. PubMed  /  PDF Grooms SY, Noh KM, Regis R, Bryan MK, Bassell, G.J., Carroll RC and Zukin RS. Activity bidirectionally regulates AMPA receptor mRNA abundance in dendrites of hippocampal neurons. Journal of Neuroscience, 2006, 26(32); 8339-8351. PubMed  /  PDF Antar LN, Li C, Zhang H, Carroll R and Bassell, G.J.. Local functions for FMRP in axon growth cone motility and activity dependent regulation of filopodia and spine synapses. Molecular and Cellular Neuroscience, 2006, 32:37-48. PubMed  /  PDF Bassell, G.J. and Twiss JL. RNA exodus to Israel: RNA controlling function in the far reaches of the neuron. Workshop on RNA control of neuronal function. EMBO Reports, 2006; 7(1):31-35. PubMed  /  PDF H¨ttelmaier S, Zenklusen D, Lederer M, Lorenz M, Dictenberg JB, Meng XH, Bassell, G.J., Condeelis J and Singer RH. Spatial regulation of β-actin translation by ZBP1. Nature, 2005;438:512-515. PubMed  /  PDF Le TT, Lan T, Pham U, Monani R, Coovert DD, Matthew ER, Gavrilin TO, Zhang HL, Bassell, G.J., Burghes AH. Expression of SMNd7, the major product of the centromeric survival motor neuron gene (SMN2), extends survival in mice with spinal muscular atrophy. Human Molecular Genetics, 2005; 14:845-857. PubMed  /  PDF Antar LN, Dictenberg JB, Bassell, G.J.. Requirement of microtubules for metabotropic glutamate receptor stimulated transport of FMRP in dendrites. Genes, Brain and Behavior, 2005; 4:350-359. PubMed  /  PDF
2003-2004
Bassell, G.J. and Kelic, S. (2004) Binding proteins for mRNA localization, local translation and their dysfunction in genetic neurological disease. Current Opinion in Neurobiology, 14:574-581. PubMed  /  PDF Smith, C.L., Afroz, R., Bassell,G.J., Furneaux,H.M., Perrone-Bizzozero,N.I. and Burry, R.W. GAP-43 mRNA in growth cones is associated with HuD and ribosomes. Journal of Neurobiology, 2004; 61: 222-235. PubMed  /  PDF Antar, L.N., Afroz, R., Dictenberg, J.B., Carroll, R.C. and Bassell, G.J. Metabotropic glutamate receptor activation regulates Fragile X Mental Retardation Protein and Fmr1 mRNA localization differentially in dendrites and at synapses. Journal of Neuroscience, 2004; 24:2468-2655. PubMed  /  PDF Eom, T., Antar, L.M., Singer, R.H. and Bassell, G.J. Localization of a β-actin mRNP complex with zipcode binding protein modulates the density of dendritic filopodia and filopodial-synapses. Journal of Neuroscience, 2003;23:10433-10444. PubMed  /  PDF Zhang, H.L., Pan, F., Hong, B., Shenoy, S.M., Singer, R.H. and Bassell, G.J. Active transport of the Survival of Motor Neuron Protein (SMN) and the role of exon-7 in cytoplasmic localization. Journal of Neuroscience, 2003;23:6627-6637. PubMed  /  PDF Dhanrajan, T.M., Oleynikov,Y., Kelic,S., Shenoy,S.M., Hartley,A., Stanton,P.K., Singer,R.H.and Bassell, G.J. Activity-dependent trafficking and dynamic localization of ZBP1 and β-actin mRNA in dendrites and spines of hippocampal neurons. Journal of Neuroscience, 2003;23:3251-3261. PubMed  /  PDF Antar,L.N. and Bassell, G.J. Sunrise at the Synapse: The FMRP mRNP Shaping the Synaptic Interface. Neuron, 2003;37:555-558. PubMed  /  PDF
1994-2002
Gu, W., Feng, P., Zhang, H.L., Bassell, G.J., and Singer, R.H. A predominantly nuclear protein affecting cytoplasmic localization of b-actin mRNA in fibroblasts and neurons. Journal of Cell Biology, 2002; 156:41-51. PubMed  /  PDF Zhang, H.L., Eom, T., Oleynikov, Y., Shenoy, S.M., Liebelt, D.A., Dictenberg, J.B., Singer, R.H. and Bassell, G.J., Neurotrophin induced transport of b-actin mRNA with Zipcode Binding Protein in neuronal processes increases b-actin levels and stimulates growth cone motility. Neuron, 2001; 31:261-275. PubMed  /  PDF Zhang, H.L., Singer, R.H. and Bassell, G.J., Neurotrophin signaling of b-actin mRNA and protein localization within growth cones. Journal of Cell Biology. 1999; 147:59-70. PubMed  /  PDF Bassell, G.J., Zhang, H.L., Byrd, A.L., Femino, A.M., Singer, R.H.,. Taneja, K.L., Lifshitz, L.M., Herman, I.M., and Kosik, K.S. Sorting of b-actin mRNA and protein to neurites and growth cones in culture. Journal of Neuroscience. 1998;18:251-265. PubMed  /  PDF Knowles, R.B., Sabry, J.H., Martonne, M.E., Deerinck, T.J., Ellisman M.H.,Bassell, G.J., and Kosik, K.S. Translocation of RNA granules in living neurons. Journal of Neuroscience. 1996; 16(24):7812-7820. PubMed  /  PDF Somasundaran, M., Zapp, M. L., Beattie, L. K., Lizhen, P., Byron, K. S., Bassell, G.J., Sullivan, J. L., and Singer, R. H. Localization of HIV RNA in mitochondria of infected cells; potential role in cytopathogenicity. Journal of Cell Biology. 1994; 126, 1353-1360. PubMed  /  PDF Bassell, G.J., Singer, R.H. and Kosik, K.S. Association of poly(A) mRNA with microtubules in cultured neurons. Neuron. 1994; 12: 571-582. PubMed Bassell, G.J., Powers, C.M., Taneja, K.L. and Singer, R.H. Single mRNAs visualized by ultrastructural in situ hybridization are principally localized at actin filament intersections. Journal of Cell Biology. 1994;126:863-876. PubMed  /  PDF
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